Every year we bring you 120+ speakers covering a wide range of topics that touch every area of your family's life. Here is a sample of our exciting speaker roster for 2013. This list is still under construction; many more will follow -- so stay tuned!
Julianne Adams, DSH-P, BCIH, NST-CP
Mark Geier, MD, PhD
Dr. Richard Moskowitz
Richard C. Deth, PhD (Pharmacology)
Brain development is driven by changes in methylation of DNA and histone proteins which combine to provide epigenetic regulation. Methylation depends upon methionine synthase and vitamin B12. B12 status in the brain is distinct from the rest of the body, and brain levels of B12 are markedly lower in autism, schizophrenia and normal aging. Recent studies of the epigenetic effects of gluten and casein-derived opiate peptides indicate their significance for development and life-long disease risk.
The ability to resist oxidation and to adapt to environmental stressors is fundamental to homeostasis, and sulfur metabolism provides the foundation for these abilities. Signaling molecules with the ability to change the redox state can exert a broad influence over cellular metabolism, including methylation-mediated epigenetic effects on gene transcription that can persist across the lifespan and even across generations. Conversely, environmental factors which interfere with redox signaling can disrupt its regulatory role, contributing to a number of disorders affecting almost every aspect of physiological function. This lecture will provide an overview of the metabolic and biochemical relationships that control the redox state of cells, including tissue-specific differences.
There is extensive evidence indicating the occurrence of oxidative stress, neuroinflammation and impaired methylation in autism and related neurodevelopmental disorders. This knowledge has assisted in identifying treatment approaches which can provide therapeutic benefit for many, but not all individuals. Autism serves to highlight the critical relationship between the GI tract and neurological/immunological development, in which epigenetic regulation plays a key role. The important role of genetic susceptibility can also be viewed within the context of redox and methylation-related metabolism. This lecture will review the scientific evidence for impaired redox and methylation status in autism, including possible causative factors and implications for treatment.
The clinician will:
Learn underlying physiological mechanisms vital to a deeper understanding of autism spectrum disorder
Understand the role of methylation in autism spectrum disorder
Understand the role of oxidative stress and inflammation in autism pathology
Understand the interrelationships of different body systems
Understand epigenetic regulation upon body systems
Dr. Deth will present recent findings of low levels of vitamin B12, methionine synthase activity and thiol metabolite status in the brain in autism, schizophrenia and aging. The influence of gluten and casein-derived opiate peptides on redox and methylation status and their epigenetic effects will also be discussed. The underlying mechanisms for these results will be reviewed in the context of the Redox/Methylation Hypothesis of Autism.