Crosstalk and modulation of purinergic, endocannabinoid, stem cell, and immune signaling from a clinical perspective

 

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Crosstalk and modulation of purinergic, endocannabinoid, stem cell, and immune signaling by CBDs, suramin, Scutellaria/baicalin, and quercetin will be discussed.

The following aspects will be included:

  •     Purinergic and endocannabinoid signaling in the regulation of the immune system
  •     Pathophysiology of purinergic signaling
  •     Role of purinergic and endocannabinoid signaling in neural, hematopoietic, and mesenchymal stem cell maintenance and differentiation
  •     Role of ectonucleotidases CD39 and CD73 in immunity and inflammation
  •     Use of CD39 and CD73 companion diagnostics to monitor efficacy of therapy targeting purinergic and endocannabinoid signaling
  •     Combination therapies targeting endocannabinoid and purinergic signaling systems