Mitochondrial dysfunction in children with autism spectrum disorder
Mitochondrial dysfunction a prevalent metabolic abnormalities in autism spectrum disorder (ASD), yet it remains poorly understood. We examined mitochondrial function in immune cell lines and fresh immune cells derived from ASD children. A significant subgroup of immune cells had mitochondrial which became dysfunctional when exposed to reactive oxygen species. These data supports the presence of a unique metabolic endophenotype of ASD children with relatively worse developmental outcomes.
Richard E. Frye, MD, PhD
Dr. Richard Frye is the Director of Autism Research at Arkansas Children's Hospital Research Institute, Director of the Autism Multispecialty Clinic at Arkansas Children's Hospital and Associate Professor in Pediatrics at the University of Arkansas for Medical Sciences. Dr. Frye is a national leader in autism research. He has authored over 100 peer-reviewed publications and book chapters, and serves on several editorial boards of prestigious scientific and medical journals.
