A Redox/Methylation Perspective on Down Syndrome
Brain development is driven by changes in methylation of DNA and histone proteins which combine to provide epigenetic regulation. Methylation depends upon methionine synthase and vitamin B12. B12 status in the brain is distinct from the rest of the body, and brain levels of B12 are markedly lower in autism, schizophrenia and normal aging. Recent studies of the epigenetic effects of gluten and casein-derived opiate peptides indicate their significance for development and life-long disease risk.
Richard C. Deth, PhD (Pharmacology)
Dr. Richard Deth is a molecular neuroscientist at Northeastern University and Florida Atlantic University. His research interests include the regulation of methylation reactions by oxidative stress and epigenetic control over gene expression in neuronal cells and brain, particularly in relation to autism, schizophrenia and Alzheimer's disease.
