Down Syndrome Trisomy 21: Understanding the Problem

Down Syndrome (DS) results from an extra copy of chromosome 21, including a number of genes on this chromosome that affect antioxidant status and methylation capacity, especially in neurons. These two factors are critical for epigenetic regulation of neural development, and are amenable to biomedical interventions. Dr. Deth will review the factors that contribute to trisomy, as well as the molecular implications of increased gene dosage for neurodevelopment and their relationship to metabolic treatment options.

Richard C. Deth

Dr. Richard Deth is Professor of Pharmacology in the Department of Pharmaceutical Sciences, School of Pharmacy, Northeastern University. His recent research has focused on the roles of oxidative stress and impaired methylation in autism, ADHD and other neurological, neuropsychiatric and neurodegenerative disorders.